吳小鵬
查看科室更多醫(yī)生
個人簡介
長期致力于流感病毒跨宿主（種間）傳播與感染機(jī)制研究,。取得了一系列原創(chuàng)性的研究成果,。主要研究成果發(fā)表在Science Immunology, JEM, Journal of Proteomics, Proteomics, Journal of Virology, Autophagy, Immunity, Nature Immunology等免疫學(xué),、病毒學(xué)高水平雜志上,。主持國家自然科學(xué)基金青年基金項目，博士后科學(xué)基金（特別資助）等項目,。
專業(yè)擅長
病毒學(xué),，免疫學(xué)結(jié)合多組學(xué)方法解析病毒感染與宿主免疫應(yīng)答對話機(jī)制。
研究方向
病毒逃逸宿主免疫應(yīng)答機(jī)制研究,；
宿主應(yīng)對病毒感染的天然免疫應(yīng)答機(jī)制研究；
宿主系統(tǒng)性免疫調(diào)控機(jī)制,。
成果獎項：（近五年主要成果及獎勵情況）
Wu, X., Khatun, A., Kasmani, M., Chen, Y., Zheng S., Samantha A., Christine N., Bunns, R., Taparowsky, E., Nita H. S., Cui W. (2021) Group 3 innate lymphoid cells require BATF to regulate gut homeostasis in mice. J Exp Med. In press.
Wu X, Kasmani MY, Zheng SK, Khatun A, Chen Y, Winkler W, Zander R, Burns R, Taparowsky EJ, Sun J, Cui WG (2022) BATF promotes group 2 innate lymphoid cell-mediated lung tissue protection during acute respiratory virus infection. Sci Immunol 7
Yang H, Winkler W, Wu X (2021) Interferon Inducer IFI35 Regulates RIG-I-Mediated Innate Antiviral Response through Mutual Antagonism with Influenza Virus Protein NS1. J Virol 95
Chen Y, Zander RA, Wu X, Schauder DM, Kasmani MY, Shen J, Zheng S, Burns R, Taparowsky EJ, Cui W (2021) BATF regulates progenitor to cytolytic effector CD8(+) T cell transition during chronic viral infection. Nat Immunol 22:996-1007
Khatun A, Kasmani MY, Zander R, Schauder DM, Snook JP, Shen J, Wu X, Burns R, Chen YG, Lin CW, Williams MA, Cui W (2021) Single-cell lineage mapping of a diverse virus-specific naive CD4 T cell repertoire. J Exp Med 218
Liu J, Wu X#, Wang HL, Wei JY, Wu Q, Wang XB, Yan Y, Cui J, Min JX, Wang FD, Zhou JY (2021) HFE inhibits type I IFNs signaling by targeting the SQSTM1-mediated MAVS autophagic degradation. Autophagy 17:1962-1977
Wang H, Wu X#, Wu X, Liu J, Yan Y, Wang F, Li L, Zhou J, Liao M (2020) Iron status is linked to disease severity after avian influenza virus H7N9 infection. Asia Pac J Clin Nutr 29:593-602
Zander R, Schauder D, Xin G, Nguyen C, Wu X, Zajac A, Cui W (2019) CD4(+) T Cell Help Is Required for the Formation of a Cytolytic CD8(+) T Cell Subset that Protects against Chronic Infection and Cancer. Immunity 51:1028-1042 e1024
