李珊
查看科室更多醫(yī)生性 別：女
最高學(xué)歷,、學(xué)位：博士
職 稱：助理研究員
院內(nèi)職務(wù)：無
個(gè)人簡(jiǎn)介
浙江大學(xué)醫(yī)學(xué)院附屬第一醫(yī)院特聘研究員,。在美國(guó)圣路易斯華盛頓大學(xué)醫(yī)學(xué)院進(jìn)行博士后訓(xùn)練,，主要研究方向?yàn)檎婧思?xì)胞內(nèi)遺傳信息質(zhì)量監(jiān)控系統(tǒng)的分子調(diào)控機(jī)制,。圍繞DNA復(fù)制壓力下應(yīng)答機(jī)制研究,，首次發(fā)現(xiàn)細(xì)胞通過激活胞漿鈣信號(hào)來維持停滯復(fù)制叉結(jié)構(gòu)穩(wěn)定性,，并發(fā)現(xiàn)cGAS-STING通過激活TRPV2介導(dǎo)的內(nèi)質(zhì)網(wǎng)鈣釋放來應(yīng)答復(fù)制壓力,，揭示了其固有免疫之外的又一非經(jīng)典功能,。利用全基因組CRISPR/Cas9敲除技術(shù)，對(duì)無義介導(dǎo)的mRNA降解途徑（NMD）的調(diào)控因子進(jìn)行了系統(tǒng)性篩選,，發(fā)現(xiàn)RNA剪切體復(fù)合物的多個(gè)組分能夠促進(jìn)NMD,，靶向NMD關(guān)鍵激酶可作為一種新的合成致死策略治療由剪接體突變?cè)斐傻募毙运柘蛋籽 Ｒ砸蛔?共同一作在Mol Cell,，Nat Commun, Cancer Res等國(guó)際學(xué)術(shù)期刊發(fā)表多篇研究論文,。
專業(yè)擅長(zhǎng)
腫瘤學(xué)和細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)
研究方向
腫瘤代謝與DNA損傷修復(fù)機(jī)制的交互調(diào)控機(jī)制;
聯(lián)合免疫療法與靶向DNA損傷修復(fù)途徑的腫瘤治療研究
成果獎(jiǎng)項(xiàng)：（近五年主要成果及獎(jiǎng)勵(lì)情況）
承擔(dān)科研項(xiàng)目:
cGAS/STING非經(jīng)典功能激活Ca2+信號(hào)通路響應(yīng)DNA復(fù)制壓力和腫瘤發(fā)生的分子機(jī)制研究, 國(guó)家自然科學(xué)基金，面上,，2023-01-01至2026-12-31,，主持
代表性的論文：
1. Shan Li*, Lingzhen Kong*, Ying Meng, Chen Cheng, Delphine Sangotokun Lemacon, Zheng Yang, Ke Tan, Abigael Cheruiyot, Zhimin Lu, Zhongsheng You. Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks. Molecular Cell, 2023, 83(4): 556-573. (Featured Article) Preview by Jungsan Sohn, Molecular Cell, 2023, 83(4):502-503.
2. Zenan Wang*, Binghao Li*, Shan Li*, Wenlong Lin, Zhan Wang, Shengdong Wang, Weida Chen, Wei Shi, Tao Chen, Hao Zhou, Eloy Yinwang, Wenkan Zhang, Haochen Mou, Xupeng Chai, Jiahao Zhang, Zhimin Lu & Zhaoming Ye (2022) Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion. Nat Commun. 6308 (2022) （*共同第一作者）
3. Abigael Cheruiyot*, Shan Li*, Sridhar Nonavinkere Srivatsan, Tanzir Ahmed, Yuhao Chen, Del-phine Sangotokun Lemacon, Ying Li, Zheng Yang, Brian A Wadugu, Wayne A. Warner, Shondra M Pruett-Miller, Esther A. Obeng, Daniel C. Link, Dalin He, Fei Xiao, Xiaowei Wang, Julie M Bailis, Matthew J Walter and Zhongsheng You (2021) Nonsense-mediated RNA Decay Is a Unique Vulnerability of Cancer Cells harboring SF3B1 or U2AF1 mutations. Cancer Research. doi: 10.1158/0008-5472.CAN-20-4016（*共同第一作者）
4. Shan Li, Zeno Lavagnino, Delphine Lemacon, Lingzhen Kong, Alessandro Ustione, Xuewen Ng, Yuanya Zhang, Yingchun Wang, Bin Zheng, Helen Piwnica-Worms, Alessandro Vindigni, David W Piston, Zhongsheng You (2019) Ca(2+)-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection. Mol Cell 74(6):1123-1137.e6. (Featured Article) Preview by Antoine Simoneau, Lee Zou, Mol Cell, 2019;74(6):1103-1105
社會(huì)任職
無
