張顯著
查看科室更多醫(yī)生科 室：骨科
性 別：男
最高學(xué)歷,、學(xué)位：研究生學(xué)歷,、博士學(xué)位
職 稱(chēng)：特聘研究員
院內(nèi)職務(wù)：無(wú)
個(gè)人簡(jiǎn)介
浙江大學(xué)醫(yī)學(xué)院附屬第一醫(yī)院特聘研究員,，碩士研究生導(dǎo)師,。本科畢業(yè)于華中科技大學(xué)藥學(xué)院,，于2013年在浙江大學(xué)醫(yī)學(xué)院碩博連讀,，主要研究課題為骨關(guān)節(jié)炎病理性力學(xué)信號(hào)介導(dǎo)分子及其干預(yù)用于骨關(guān)節(jié)炎治療的研究,，獲干細(xì)胞與再生醫(yī)學(xué)專(zhuān)業(yè)博士學(xué)位,。2018年至2022年在浙江大學(xué)歐陽(yáng)宏偉教授課題組從事博士后研究,，主要課題為骨損傷再生過(guò)程中關(guān)鍵干細(xì)胞亞群的鑒定與再生機(jī)制研究。2023年起加入浙江大學(xué)醫(yī)學(xué)院附屬第一醫(yī)院任特聘研究員,。長(zhǎng)期從事基于生物活性成分及干細(xì)胞的骨,、軟骨組織工程方面的研究。已在Nature Communications,、Biomaterials,、Advanced Healthcare Materials,、Acta biomateralia、ACS Applied Materials & Interfaces,、Journal of Orthopaedic Translation等SCI期刊發(fā)表學(xué)術(shù)論文24篇,，累計(jì)被引用次數(shù)超過(guò)1179次，H指數(shù)12,。
研究方向
基于骨骼干細(xì)胞亞群和生物活性材料的骨組織工程研究,；基于單細(xì)胞多組學(xué)解析骨再生過(guò)程中再生細(xì)胞事件的研究等。
成果獎(jiǎng)項(xiàng)：（近五年主要成果及獎(jiǎng)勵(lì)情況）
1） Xianzhu Zhang#, Wei Jiang#, Chang Xie#, Xinyu Wu, Qian Ren, Fei Wang, Xilin Shen, Yi Hong, Hongwei Wu, Youguo Liao, Yi Zhang, Renjie Liang, Wei Sun, Yuqing Gu, Tao Zhang, Yishan Chen, Wei Wei, Shufang Zhang, Weiguo Zou, Hongwei Ouyang*. Msx1+ stem cells recruited by bioactive tissue engineering graft for bone regeneration. Nature Communications. 2022. Sep 5;13(1):5211.
2） Xianzhu Zhang, Dandan Cai, Feifei Zhou, Jie Yu, Xinyu Wu, Dongsheng Yu, Yiwei Zou, Yi Hong, Chunhui Yuan, Yishan Chen, Zongyou Pan, Varitsara Bunpetch, Heng Sun, Chengrui An, Toh Yi-Chin, Hongwei Ouyang*, Shufang Zhang*. Targeting downstream subcellular YAP activity as a function of matrix stiffness with Verteporfin-encapsulated chitosan microsphere attenuates osteoarthritis. Biomaterials. 2020 Feb;232:119724.
3） Chang Xie#, Renjie Liang#, Jinchun Ye#, Zhi Peng, Qiuwen Zhu, Xilin Shen, Yi Hong, Hongwei Wu, Wei Sun, Xudong Yao, Jiajin Li, Shufang Zhang, Xianzhu Zhang*(Co-corresponding), Hongwei Ouyang*. High-efficient engineering of osteo-callus organoids for rapid bone regeneration within one month. Biomaterials. 2022 Sep;288:121741.
4） Jingwei Zhang#, Xianzhu Zhang#(Co-first author), Yi Hong, Qianbao Fu, Qiulin He, Asma Mechakra, Qiuwen Zhu, Feifei Zhou, Renjie Liang, Chenglin Li, Yejun Hu, Yiwei Zou, Shufang Zhang, Hongwei Ouyang*. Tissue-Adhesive Paint of Silk Micro-particles for Articular Surface Cartilage Regeneration. ACS Appl. Mater. Interfaces. 2020, 12, 20, 22467–22478.
5） Feifei Zhou#, Xianzhu Zhang#(Co-first author), Dandna Cai, Jun Li, Qin Mu, Wei Zhang, Shouan Zhu, Yangzi Jiang, Weiliang Shen, Shufang Zhang*, Hongwei Ouyang. Silk Fibroin-Chondroitin Sulfate Scaffold with Immuno-inhibition Property for Articular Cartilage Repair. Acta Biomater, 2017 Nov;63:64-75.
6） Wei, Wei#; Ma, Yuanzhu#; Zhang, Xianzhu#(Co-first author); Zhou, Wenyan#; Wu, Hongwei; Zhang, Jingwei; Lin, Ju nxin; Tang, Chenqi; Liao, Youguo; Li, Chenglin; Wang, Xiaozhao; Yao, Xudong; Koh, Yi Wen; Huang, Wenwen; Hongwei Ouyang*; Biomimetic Joint Paint for Efficient Cartilage Repair by Simultaneously Regulating Cartilage Degeneration and Regeneration in Pigs. ACS Appl Mater Interfaces, 2021, 13( 46): 54801-54816.
Chang Xie; Jinchun Ye; Renjie Liang; Xudong Yao; Xinyu Wu; Yiwen Koh; Wei Wei; Xianzhu Zhang*(Co-corresponding); Hongwei Ouyang*; Advanced Strategies of Biomimetic Tissue-Engineered Grafts for Bone Regeneration. Advanced Healthcare Materials, 2021, 10(14).
社會(huì)任職
中國(guó)生物醫(yī)學(xué)工程學(xué)會(huì)會(huì)員,；Journal of Visualized Experiemnts期刊客座編輯,，ACS Biomaterials Science & Engineering， iScience等國(guó)際知名期刊特邀評(píng)審專(zhuān)家,。
