趙焜
查看科室更多醫(yī)生科 室：血液科骨髓移植中心
性 別：男
最高學(xué)歷,、學(xué)位：博士
職 稱：助理研究員
院內(nèi)職務(wù)：特聘副研究員
個(gè)人簡(jiǎn)介
長(zhǎng)期從事基于冷凍電鏡的蛋白質(zhì)結(jié)構(gòu)研究,，包括：蛋白聚集體結(jié)構(gòu)及病理研究，基于蛋白結(jié)構(gòu)的小分子抑制劑篩選,，以及蛋白受體結(jié)構(gòu)和功能研究。近年來(lái)在Nature Structural & Molecular Biology,， Nature Communications, Science Advances, Cell Research, PNAS等雜志發(fā)表多篇文章,。
專業(yè)擅長(zhǎng)
蛋白質(zhì)結(jié)構(gòu)和病理研究
研究方向
血液病相關(guān)淀粉樣纖維結(jié)構(gòu)及病理研究；基于冷凍電鏡結(jié)構(gòu)的蛋白質(zhì)抑制劑或示蹤劑篩選,。
成果獎(jiǎng)項(xiàng)：（近五年主要成果及獎(jiǎng)勵(lì)情況）
1. Kun Zhao*, Yaowang Li*, Zhenying Liu, Houfang Long, Chunyu Zhao, Feng Luo, Yunpeng Sun, Youqi Tao, Xiao-dong Su, Dan Li, Xueming Li, Cong Liu. Parkinson's disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure, Nature Communications, 2020, 11(1):2643
2. Kun Zhao*, Yeh-Jun Lim*, Zhenying Liu*, Houfang Long, Yunpeng Sun, Jin-Jian Hu, Chunyu Zhao, Youqi Tao, Xing Zhang, Dan Li, Yan-Mei Li, Cong Liu. Parkinson’s disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM, PNAS, 2020, 117(33):20305-20315
3. Yunpeng Sun*, Kun Zhao*, Wencheng Xia, Guoqin Feng, Jinge Gu, Yeyang Ma, Xinrui Gui, Xia Zhang, Yanshan Fang, Bo Sun, Renxiao Wang, Cong Liu, Dan Li. The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure, Nature Communications, 2020, 11(1):6349
4. Li-Qiang Wang*, Kun Zhao*, Han-Ye Yuan, Qiang Wang, Zeyuan Guan, Jing Tao, Xiang-Ning Li, Yunpeng Sun, Chuan-Wei Yi, Jie Chen, Dan Li, Delin Zhang, Ping Yin, Cong Liu, Yi Liang. Cryo-EM structure of an amyloid fibril formed by full-length human prion protein, Nature Structural & Molecular Biology, 2020, 27(6):598–602
5. Li-Qiang Wang*, Kun Zhao*, Han-Ye Yuan*, Xiang-Ning Li, Hai-Bin Dang, Yeyang Ma, Qiang Wang, Chen Wang, Yunpeng Sun, Jie Chen, Dan Li, Delin Zhang, Ping Yin, Cong Liu, Yi Liang. Genetic prion disease-related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM, Science Advances, 2021, 7(37)
6. Yunpeng Sun*, Shouqiao Hou*, Kun Zhao*, Houfang Long, Zhenying Liu, Jing Gao, Yaoyang Zhang, Xiao-Dong Su, Dan Li, Cong Liu. Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson's disease familial A53T mutation, Cell Research, 2020, 30(4):360–362
7. Xialian Wu*, Yeyang Ma*, Kun Zhao*, Jing Zhang, Yunpeng Sun, Yichen Li, Xingqi Dong, Hong Hu, Jing Liu, Jian Wang, Xia Zhang, Bing Li, Huayi Wang, Dan Li, Bo Sun, Junxia Lu, and Cong Liu. The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3, PNAS, 2021, 188(14)
社會(huì)任職
無(wú)
