孫澤宇
查看科室更多醫(yī)生性 別：男
最高學(xué)歷、學(xué)位：博士學(xué)歷,，博士學(xué)位
職 稱：助理研究員
個(gè)人簡(jiǎn)介
美國(guó)科羅拉多州立大學(xué)博士，浙江大學(xué)博士后,，傳染病重癥診治全國(guó)重點(diǎn)實(shí)驗(yàn)室助理研究員,，蛋白質(zhì)譜平臺(tái)負(fù)責(zé)人，生物大分子質(zhì)譜應(yīng)用專家,，研究方向?yàn)樯镔|(zhì)譜檢測(cè)方法的開(kāi)發(fā),，采用蛋白/代謝組學(xué)手段開(kāi)發(fā)疾病標(biāo)志物研發(fā)并開(kāi)展感染性疾病機(jī)制研究。先后于MCP,、JCI,、Anal Chem、Engineering,、Theranostics等組學(xué),、醫(yī)學(xué)及化學(xué)TOP期刊上發(fā)表41篇SCI文章。先后主持中國(guó)博士后基金一項(xiàng),、國(guó)家自然科學(xué)基金2項(xiàng),、國(guó)家重點(diǎn)研發(fā)計(jì)劃子任務(wù)2項(xiàng)、浙江省醫(yī)藥衛(wèi)生科技計(jì)劃各一項(xiàng),，參與863計(jì)劃,，國(guó)家重點(diǎn)研發(fā)計(jì)劃及自然科學(xué)基金多項(xiàng)。
專業(yè)擅長(zhǎng)
擅長(zhǎng)大分子生物質(zhì)譜技術(shù)應(yīng)用,，蛋白組學(xué)與翻譯后修飾組學(xué),，感染性疾病與重癥化感染標(biāo)志物開(kāi)發(fā)，病原體-宿主互作機(jī)制研究,。蛋白組生物信息學(xué)軟件和多組學(xué)大數(shù)據(jù)統(tǒng)計(jì)流程,。
研究方向
重癥肝炎預(yù)警標(biāo)志物和發(fā)病機(jī)制研究；利用蛋白組學(xué)和翻譯后修飾組學(xué)挖掘病毒-宿主作用靶標(biāo)與機(jī)制研究,；代謝物調(diào)控免疫與炎癥反應(yīng)的機(jī)制研究,；新型大分子生物質(zhì)譜技術(shù)開(kāi)發(fā)與應(yīng)用研究。
成果獎(jiǎng)項(xiàng)：（近五年主要成果及獎(jiǎng)勵(lì)情況）
Daxian Wu#, Sainan Zhang#, Er’mei Chen, Qunfang Rao, Xiaoli Liu, Zhongyang Xie, Kaizhou Huang, Jing Yang, Lanlan Xiao, Feiyang Ji, Zhengyi Jiang, Yalei Zhao, Xiaoxi Ouyang, Danhua Zhu, Xiahong Dai, Zhouhua Hou, Bingjie Liu, Binbin Deng, Ning Zhou, Hainv Gao, Zeyu Sun*, Lanjuan Li*, Plasminogen as a prognostic biomarker for HBV-related acute-on-chronic liver failure, Journal of Clinical Investigation, 2020, Apr 1;130(4):2069-2080. (IF：14.8)
Zeyu Sun#, Wei Li#, Jialu Xu, Keyi Ren, Feng Gao, Feiyang Ji, Dongli Pan*, Proteomic analysis of cerebrospinal fluid in children with acute enterovirus-associated meningoencephalitis identifies dysregulated host processes and potential biomarkers, Journal of Proteome Research, Jul 17, 2020.19, 8:3487–3498 (IF：4.5)
Zhengyi Jiang#, Zeyu Sun#, Xiaoxi Ouyang#, Yalei Zhao#, Menghao Zhou, Baohong Wang, Qirui Li, Linxiao Fan, Sainan Zhang, Lanjuan Li*, Temporal Integrative Omics Reveals an Increase in Nondegradative Ubiquitylation during Primary Hepatocyte Dedifferentiation, Engineering, 2020, Nov, 6(11), 1302-1314 (IF：7.5)
Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li*. Mass spectrometry analysis of newly emerging coronavirus HCoV-19 spike protein and human ACE2 reveals camouflaging glycans and unique post-translational modifications, Engineering, 2021, Oct , 7(10), 1441-1451 (IF：12.8)
Pengyan Wang, Can Yue, Kefang Liu, Dan Lu, Sai Liu, Sijia Yao, Xiaoling Su, Keyi Ren, Yan Chai, Jianxun Qi, Yongliang Lou, Zeyu Sun*, George Gao*, William Liu*, Peptide presentations of marsupial MHC I visualize immune features of lower mammals paralleled with bats, The Journal of Immunology, 2021, Oct 15;207(8):2167-2178. (IF：5.4)
Zeyu Sun#, Xiaoqin Zheng#, Feiyang Ji, Menghao Zhou, Xiaoling Su, Keyi Ren, Lanjuan Li*, Mass Spectrometry Analysis of Coronavirus SARS-CoV-2 Nucleocapsid Protein Reveals Camouflaging Glycans and Unique Post-Translational Modifications, Infectious Microbes and Diseases, 2021, 3(3):149-157
Feiyang Ji#, Menghao Zhou#, Zeyu Sun#, Zhengyi Jiang#, Huihui Zhu, Zhongyang Xie, Xiaoxi Ouyang, Lingjian Zhang, Lanjuan Li*, Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis, Cancer Communications, 2021 Oct;41(10):1007-1023. (IF：10.4)
Zeyu Sun#, Chenjie Huang#, Yixian Shi, Rusha Wang, Jun Fan, Ye Yu, Zhehua Zhang, Kundan Zhu, Minwei Li, Qin Ni, Zhi Chen, Min Zheng*, Zhenggang Yang*, Distinct bile acid profiles in patient with chronic hepatitis B virus infection reveal metabolic interplay between host, virus and gut microbiome, Frontiers of Medicine, 2021, Oct 4, 8:708495 (IF：4.6)
Xiaoqin Zheng#, Zeyu Sun#, Liang Yu, Danrong Shi, Miaojin Zhu, Hangping Yao*, Lanjuan Li*, Interactome analysis of the nucleocapsid protein of SARS-CoV-2 virus, Pathogens, 2021, Sep 8;10(9):1155 (IF：3.5)
Yinping Tian#, Qiang Zhu#, Zeyu Sun#, Didi Geng, Bingyi Lin, Xiaoling Su, Jiahui He, Miao Guo, Hong Xu, Ye Zhao, Weijie Qin, Peng George Wang, Liuqing Wen, Wen Yi, One-step enzymatic labeling reveals a critical role of O-GlcNAcylation in cell-cycle progression and DNA damage response, Angewandte Chemie, 2021, Dec 6;60(50):26128-26135. (IF：12.9)
Jialu Xu#, Zeyu Sun#, Wei Li, Lifang Liu, Feng Gao, Dongli Pan*, Epidemiological characteristics and cerebrospinal fluid cytokine profiles of enterovirus encephalitis in children in Hangzhou, China, Journal of Medical Virology, 2022, Jun;94(6):2645-2652. (IF：2.3)
Fujun Hou#, Zeyu Sun#, Yue Deng, Siyu Chen, Xiyuan Yang, Ji Feiyang, Menghao Zhou, Keyi Ren, Dongli Pan*, Interactome and ubiquitinome analyses identify functional targets of herpes simpex virus 1 ICP0, Frontiers in Microbiology, 2022, Apr 18;13:856471 (IF：5.6)
Daxian Wu, Qunfang Rao, Zhongyang Xie, Xiaoqing Zhu, Yuanmei Che, Jian Wu, Hainv Gao, Jingyu Zhang, Zhouhua Hou, Xiaoyu Cheng*, Zeyu Sun*, Decreased vitamin D-binding protein level portends poor outcome in acute-on-chronic liver failure caused by hepatitis B virus, Clinical and Molecular Hepatology, 2022 Oct;28(4):912-925. doi: 10.3350/cmh.2022.0121
Qixia Luo, Yu Wang, Xiaoling Su, Xue Yang, Zeyu Sun*, Proteomic characterization of human gut habitual Bacteroides intestinalis against common intestinal bile acids stress, Advanced Gut & Microbiome Research, 2023, May 23; 8395946
Huili Liu, Jun Wang, Yan Zhang, Jing Gu, Yu Wang, Yongxing Yan*, Dongli Pan*, Zeyu Sun*, Cerebrospinal ?uid proteomics in meningitis patients with reactivated varicella zoster virus, Immunity, Inflammation and Disease, 2023 Oct;11(10):e1038. doi: 10.1002/iid3.1038 (IF：3.2)
Yang Yu, Peng Sun, Yan Liu, Wan-lu Zhao, Teng-jian Wang, Shuang-xia Yu, Lin-Kun Tian, Lin Zhao, Min-min Zhang, Qiao-yan Zhang, Ze-yu Sun*, Quanlong Zhang*, Lu-ping Qin*, Characterization and evaluation of the in vitro and in vivo anti-diabetic activities of camel milk protein hydrolysates derived with different protease digestions, Journal of Functional Foods, 2024:106227 (IF：5.6)
Jianing Zhang, Can Yue, Yin Lin, Jinmin Tian, Yuanyuan Gao, Danni Zhang, Yanxin Guo, Beiwei Ye, Yan Chai, Jianxun Qi, Yingze Zhao, George Gao*, Zeyu Sun*, Jun Liu*, Uncommon P1 Anchor-featured Viral T Cell Epitope Preference within HLA-A*2601 and HLA-A*0101 Individuals, ImmunoHorizons, 2024, Jun 1;8(6):415-430.
2023年度中華醫(yī)學(xué)科技獎(jiǎng)《重要疫源微生物組的研究與發(fā)現(xiàn)》
2024年 浙江省第四屆“檢測(cè)家杯”優(yōu)秀論文獎(jiǎng)《基于高分辨質(zhì)譜和從頭測(cè)序算法的蛋白SUMO組學(xué)研究》
2020/2021/2023 浙江大學(xué)醫(yī)學(xué)院先進(jìn)工作者
社會(huì)任職
浙江省分析測(cè)試協(xié)會(huì)生物大分子專委會(huì),，常委,；浙江省數(shù)理醫(yī)學(xué)學(xué)會(huì)生物醫(yī)學(xué)大數(shù)據(jù)專委會(huì)委員；中國(guó)轉(zhuǎn)化醫(yī)學(xué)聯(lián)盟暨中國(guó)精準(zhǔn)醫(yī)學(xué)學(xué)會(huì) 會(huì)員,；美國(guó)化學(xué)工程師協(xié)會(huì)(AIChE),，會(huì)員；美國(guó)質(zhì)譜學(xué)會(huì)(ASMS)，會(huì)員; Journal of Proteome Research, Molecular and Cellular Biochemistry, 中國(guó)細(xì)胞生物學(xué)學(xué)報(bào),，F(xiàn)rontiers in Bioscience-Landmark, BMC Genomics等審稿人
