章京
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出診信息
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個人簡介
教授,，博士生導師,。浙大醫(yī)學院附屬第一醫(yī)院余杭院區(qū)副院長,，病理科主任了,，中國健康和疾病人腦組織庫主任。曾任華盛頓大學醫(yī)學院神經(jīng)病理科主任,、北京大學基礎醫(yī)學院病理系/北醫(yī)三院病理科主任,。擔任許多世界級神經(jīng)科學雜志，如American Journal of Pathology,，Brain Pathology,，Neurological Disease，Neurochemical Res等的編委,，并擔任Science,，Nature 和PNAS等眾多國際知名科學雜志的審稿人。同時,，還常年作為美國NIH 基金評委,，也連續(xù)多年作為中國國家自然科學基金二審評委。2017年6月,，代表中國病理學界成功地獲得了2019年亞太國際病理大會在中國舉辦權,。在國際神經(jīng)病理學術界享有極高聲譽,。發(fā)表文章約250篇SCI文章，其中包括世界頂級雜志,，如Lancet Neurology,，Acta Neuropathologica，Science Translational Medicine,，Alzheimers & Dementia等,，總引用次數(shù)超過17,000次，h-指數(shù)71,，i10-指數(shù)199,。
專業(yè)擅長
神經(jīng)病理 （神經(jīng)腫瘤及神經(jīng)退行性疾病）,。團隊在神經(jīng)退行性疾病早期診斷生物標志物研究與轉(zhuǎn)化應用領域處于國際領先地位,，尤其是在外周體液分離和鑒定中樞神經(jīng)系統(tǒng)來源生物標志物領域，更是處于行業(yè)引領地位,，擁有多項國際/國內(nèi)專利技術,。在阿爾茨海默病（Alzheimer’s disease,，AD）和帕金森?。≒arkinson’s disease，PD）的早期診斷生物標志物研究方面,，章京教授發(fā)表的文章在數(shù)量和質(zhì)量上均處于國際同行的第一陣列,。
研究方向
神經(jīng)退行性疾病早期診斷生物標志物研究與轉(zhuǎn)化應用，從外周體液中分離和鑒定中樞神經(jīng)系統(tǒng)疾病生物標志物新技術研發(fā)等,。
成果獎項：（近五年主要成果及獎勵情況）
1. Zhenwei Yu #, Min Shi#, Tessandra Stewart, Pierre-Olivier Fernagu, Yang Huang, Chen Tian, Benjamin Dehay, Anzari Atik, Dishun Yang, Francesca De Giorgi, Franc?ois Ichas, Marie-Hélène Canron, Roberto Ceravolo, Daniela Frosini, Han-Joon Kim, Tao Feng, Wassilios G Meissner*, Jing Zhang*. Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction[J]. Brain, 2020.2.23 Received, will online in 2020.June.SCI
2. Li N#, Wu Y, Zhu L, Huang Y, Liu Z, Shi M, Soltys D, Zhang J*, Chang Q* Extracellular microvesicles-derived from microglia treated with unaggregated α-synuclein attenuate mitochondrial fission and toxicity-induced by Parkinsonian toxin MPP.[J]. Biochem Biophys Res Commun. 2019 Oct 1;517(4):642-647. SCI
3. Chen Tian#, Genliang Liu, Liyan Gao, David Soltys, Catherine Pan, Tessandra Stewart, Min Shi, Zhiying Xie, Na Liu, Tao Feng *, Jing Zhang *.Erythrocytic α-Synuclein as a potential biomarker for Parkinson’s disease[J]. Translational Neurodegeneration, 2019, 8(1). SCI
4. Yong‐Xiao Li#, Zhen‐Wei Yu#, Tao Jiang, Li‐Wei Shao, Yan Liu, Na Li, Yu‐Feng Wu, Chen Zheng, Xiao‐Yu Wu, Ming Zhang, Dan‐Feng Zheng, Xue‐Ling Qi, Min Ding, Jing Zhang*, Qing Chang*.SNCA, a novel biomarker for Group 4 medulloblastomas, can inhibit tumor invasion and induce apoptosis. Cancer science. 2018,109(4) :1263-1275.SCI
5. Hua Wang#, Tessandra Stewart, Jon B Toledo, Carmen Ginghina, Lu Tang, Anzari Atik, Patrick Aro, Leslie M Shaw, John Q Trojanowski, Douglas R Galasko, Steven Edland, Poul H Jensen, Min Shi, Jing Zhang*.A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer’s Disease and Mild Cognitive Impairment. Journal of Alzheimer's Disease. 2018,61(4):1541-1553.SCI
6. Zhenwei Yu#, Tessandra Stewart, Jan Aasly, Min Shi, Jing Zhang*.Combining clinical and biofluid markers for early Parkinson's disease detection. Annals of clinical and translational neurology. 2018,5(1):109-114.SCI
7. Hua Wang#, Anzari Atik, Tessandra Stewart, Carmen Ginghina, Patrick Aro, Kathleen F Kerr, John Seibyl, Danna Jennings, Poul Henning Jensen, Kenneth Marek, Min Shi, Jing Zhang*.Plasma α-synuclein and cognitive impairment in the Parkinson's Associated Risk Syndrome: A pilot study. Neurobiology of disease. 2018,116:53-59.SCI
8. Min Shi#, Lu Tang#, Jon B Toledo, Carmen Ginghina, Hua Wang, Patrick Aro, Poul H Jensen, Daniel Weintraub, Alice S Chen-Plotkin, David J Irwin, Murray Grossman, Leo McCluskey, Lauren B Elman, David A Wolk, Edward B Lee, Leslie M Shaw, John Q Trojanowski, Jing Zhang*.Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease. Alzheimer's & Dementia. 2018,14(8):1052-1062.SCI
9. William A Banks#, Andrej Kovac, Petra Majerova, Kristin M Bullock, Min Shi, Jing Zhang*.Tau Proteins Cross the Blood-Brain Barrier. Journal of Alzheimer's Disease. 2017,55(1):411-419.SCI
10. Junichi Matsumoto#, Tessandra Stewart, William A Banks, Jing Zhang*.The transport mechanism of extracellular vesicles at the blood-brain barrier. Current pharmaceutical design. 2017,23(40):6206-6214.SCI
11. Ingrid Chang, Gordana Juric-Sekhar, Desiree Marshall, Jing Zhang*.An incidental finding of choroidal ganglioneuronal hamartoma in a patient with neurofibromatosis type 1. Ophthalmic plastic and reconstructive surgery. 2017,33(3):S40-S42.SCI
12. Min Shi#, Andrej Kovac, Ane Korff, Travis J Cook, Carmen Ginghina, Kristin M Bullock, Li Yang, Tessandra Stewart, Danfeng Zheng, Patrick Aro, Anzari Atik, Kathleen F Kerr, Cyrus P Zabetian, Elaine R Peskind, Shu-Ching Hu, Joseph F Quinn, Douglas R Galasko, Thomas J Montine, William Banks, Jing Zhang*.CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease. Alzheimer's & dementia: the journal of the Alzheimer's Association. 2016,12(11):1125-1131.SCI
13. Shijun Wang#, Chun-Hsien Chu, Mingri Guo, Lulu Jiang, Hui Nie, Wei Zhang, Belinda Wilson, Li Yang, Tessandra Stewart, Jau-Shyong Hong, Jing Zhang*.Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons. Journal of neuroinflammation. 2016,13(1):158.SCI
14. Xiangmin Lin#, Min Shi, Jeyaraj Gunasingh Masilamoni, Romel Dator, James Movius, Patrick Aro, Yoland Smith, Jing Zhang*.Proteomic profiling in MPTP monkey model for early Parkinson disease biomarker discovery. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics. 2015,1854(7):779-787.SCI
15. Shijun Wang#, Chun-Hsien Chu, Tessandra Stewart, Carmen Ginghina, Yifei Wang, Hui Nie, Mingri Guo, Belinda Wilson, Jau-Shyong Hong, Jing Zhang*.α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation. Proceedings of the National Academy of Sciences. 2015,112(15):E1926-E1935.SCI
16. Min Shi#, James Movius, Romel Dator, Patrick Aro, Yanchun Zhao, Catherine Pan, Xiangmin Lin, Theo K Bammler, Tessandra Stewart, Cyrus P Zabetian, Elaine R Peskind, Shu-Ching Hu, Joseph F Quinn, Douglas R Galasko, Jing Zhang*.Cerebrospinal fluid peptides as potential Parkinson disease biomarkers: a staged pipeline for discovery and validation. Molecular & Cellular Proteomics. 2015,14(3):544-555.SCI
17. Tianfang Jiang#, Jake Hoekstra, Xin Heng, Wenyan Kang, Jianqing Ding, Jun Liu, Shengdi Chen, Jing Zhang*.P2X7 receptor is critical in α-synuclein–mediated microglial NADPH oxidase activation. Neurobiology of aging. 2015,36(7):2304-2318.SCI
18. Ge Li#, Kangping Xiong, Ane Korff, Catherine Pan, Joseph F Quinn, Douglas R Galasko, Chunfeng Liu, Thomas J Montine, Elaine R Peskind, Jing Zhang*.Increased CSF E-Selectin in Clinical Alzheimer’s Disease without Altered CSF A β 42 and Tau. Journal of Alzheimer's Disease. 2015,47(4):883-887.SCI
19. Changqin Liu#, Brenna Cholerton, Min Shi, Carmen Ginghina, Kevin C Cain, Peggy Auinger, Jing Zhang*.CSF tau and tau/Aβ42 predict cognitive decline in Parkinson's disease. Parkinsonism & related disorders. 2015,21(3):271-276.SCI
20. Catherine Pan#, Ané Korff, Douglas Galasko, Carmen Ginghina, Elaine Peskind, Ge Li, Joseph Quinn, Thomas J Montine, Kevin Cain, Min Shi, Jing Zhang*.Diagnostic Values of Cerebrospinal Fluid T-Tau and Aβ 42 using Meso Scale Discovery Assays for Alzheimer's Disease. Journal of Alzheimer's Disease. 2015,45(3):709-719.SCI
社會任職
世界病理學會中國分會秘書長
中國神經(jīng)科學學會神經(jīng)退行性疾病分會副主任委員
