梁臻
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出診信息
注：出診時間如有變化,，以當日掛號為準| 門診時間 | 門診地點 |
|---|---|
| 星期 六 (上午) | 總部一期 |
| 星期 四 (上午) | 總部一期 |
| 星期 六 (下午) | 總部一期 |
個人簡介
畢業(yè)于浙江大學醫(yī)學院,，獲臨床醫(yī)學博士學位，長期從事泌尿外科臨床一線工作,，擅長泌尿系結石及各類腫瘤的診斷及微創(chuàng)手術治療,；參研國家自然科學基金面上項目1項，青年基金3項,；以第一作者身份發(fā)表SCI論文5篇(其中IF>5分者3篇）,，參與發(fā)表SCI論文十余篇,。
專業(yè)擅長
泌尿系結石及泌尿系腫瘤的微創(chuàng)手術，尤其擅長腎臟及前列腺相關疾病的外科治療,。
研究方向
泌尿系腫瘤的早期分子診斷及表觀遺傳學調控
成果獎項：（近五年主要成果及獎勵情況）
主參課題：1.國家自然科學基金青年項目,，81502215，靶向增強子的小激活RNA激活前列腺癌細胞E-鈣粘蛋白表達的機制初探,，2016.01-2018.12。
2.國家自然科學基金青年項目,，81702500,，c-Met和DLK1-DIO3印記域miRNA簇之間的調控環(huán)路在膀胱癌惡性行為中的作用及其機制研究，2018.01-2020.12,。
3. 國家自然科學基金面上項目,，81874203，METTL3/YTHDF2 m6A軸介導的circ-DNMT3b
的競爭性表達調控及其在膀胱癌順鉑耐藥中的機制研究,，2019.01-2022.12,。
4.國家自然科學基金青年項目，81772744,，YTHDF2通過轉錄后調控m6A修飾的NKX3.1介導AKT/GSK3β通路在前列腺癌中的作用及分子機制研究,，2019.01-2022.12。
主要論文（第一作者）：
（1）Liang Z, Wang X, Xu X, Xie B, Ji A, Meng S, Li S, Zhu Y, Wu J, Hu Z, Lin Y, Zheng X, Xie L*, Liu B*. MicroRNA-608 inhibits proliferation of bladder cancer via AKT/FOXO3a signaling pathway. Molecular Cancer.2017, 16(1):96.
（2）Liang Z, Wang X, Xie B, Zhu Y, Wu J, Li S, Meng S, Zheng X, Ji A*, Xie L. Pesticide exposure and risk of bladder cancer: A meta-analysis. Oncotarget. 2016
（3）Wang X#, Liang Z#, Xu X, Li J, Zhu Y, Meng S, Li S, Wang S, Xie B, Ji A, Liu B, Zheng X, Xie L*. miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer. Cell Death Dis. 2016 Dec 1; 7(12):e2503.（加#者為共同第一作者）
（4）Liang Z, Xie B, Li J, Wang X, Wang S, Meng S, Ji A, Zhu Y, Xu X, Zheng X, Xie L*. Hypertension and risk of prostate cancer: a systematic review and meta-analysis. Sci Rep. 2016 Aug 11; 6:31358.
（5）Liang Z, Li S, Xu X, Xu X, Wang X, Wu J, Zhu Y, Hu Z, Lin Y, Mao Y, Chen H,Luo J, Liu B, Zheng X, Xie L*. MicroRNA-576-3p inhibits proliferation in bladder cancer cells by targeting cyclin D1. Mol Cells. 2015;38(2):130-7.
參與發(fā)表論文：
1）Shu Y, Ren L, Xie B, Liang Z, Chen J*.miR-204 enhances mitochondrial apoptosis in doxorubicin-treated prostate cancer cells by targeting SIRT1/p53 pathway. Oncotarget. 2017 Oct 23;8(57):97313-97322.
(2) Li J, Xu X, Meng S, Liang Z, Wang X, Xu M, Wang S, Li S, Zhu Y, Xie B, Lin Y, Zheng X, Liu B,Xie L*. MET/SMAD3/SNAIL circuit mediated by miR-323a-3p is involved in regulating epithelial-mesenchymal transition progression in bladder cancer. Cell Death Dis. 2017 Aug 24;8(8):e3010.
（3）Xu X, Li J, Wang X, Wang S, Meng S, Zhu Y, Liang Z, Zheng X, Xie L*. Tomato consumption and prostate cancer risk: a systematic review and meta-analysis. Sci Rep. 2016 Nov 14;6:37091
（4） Xu X, Zhu Y, Liang Z, Li S, Xu X, Wang X, Wu J, Hu Z, Meng S, Liu B, Qin J, Xie L*, Zheng X*. c-Met and CREB1 are involved in miR-433-mediated inhibition of the epithelial-mesenchymal transition in bladder cancer by regulating Akt/GSK-3β/Snail signaling. Cell Death Dis. 2016 Feb 4;7:e2088.
（5）Xie B, Hu Y, Liang Z, Liu B, Zheng X, Xie L*. Association between pesticide exposure and risk of kidney cancer: a meta-analysis. Onco Targets Ther. 2016 Jun 28;9:3893-900.
（6）Li S, Zhu Y, Liang Z, Wang X, Meng S, Xu X, Xu X, Wu J, Ji A, Hu Z, Lin Y, Chen H, Mao Y, Wang W, Zheng X, Liu B, Xie L*. Up-regulation of p16 by miR-877-3p inhibits proliferation of bladder cancer. Oncotarget.
2016 Jul 13.
（7）Wang X, Ji A, Zhu Y, Liang Z, Wu J, Li S, Meng S, Zheng X, Xie L*. A meta-analysis including dose-response relationship between night shift work and the risk of colorectal cancer. Oncotarget. 2015 Sep 22;6(28):25046-60.
（8） Zhu Y, Wu J, Li S, Wang X, Liang Z, Xu X, Xu X, Hu Z, Lin Y, Chen H, Qin J, Mao Q, Xie L*. Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer. Mol Med Rep. 2015 Feb;11(2):1004-8.
（9）Wang X, Lin YW, Wu J, Zhu Y, Xu XL, Xu X, Liang Z, Hu ZH, Li SQ, Zheng XY, Xie LP*. Meta-analysis of nonsteroidal anti-inflammatory drug intake and prostate cancer risk. World J Surg Oncol. 2014 Oct 5;12:304.
（10） Wang X, Wu J, Lin Y, Zhu Y, Xu X, Xu X, Liang Z, Li S, Hu Z, Zheng X, Xie L*. MicroRNA-320c inhibits tumorous behaviors of bladder cancer by targeting Cyclin-dependent kinase 6. J Exp Clin Cancer Res. 2014 Sep 2;33:69.
（11） Xu X, Wu J, Li S, Hu Z, Xu X, Zhu Y, Liang Z, Wang X, Lin Y, Mao Y, Chen H, Luo J, Liu B, Zheng X, Xie L*. Downregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via activating the AKT/FOXO3a signaling pathway. Mol Cancer. 2014 May 17;13:109.
（12）Wu J, Ji A, Wang X, Zhu Y, Yu Y, Lin Y, Liu Y, Li S, Liang Z, Xu X, Zheng X, Xie L*. MicroRNA-195-5p, a new regulator of Fra-1, suppresses the migration and invasion of prostate cancer cells. J Transl Med. 2015 Sep 4;13:289.
