呂志民
查看科室更多醫(yī)生
個人簡介
浙江大學(xué)轉(zhuǎn)化醫(yī)學(xué)研究院教授,，浙江大學(xué)王寬誠杰出講席教授,，浙江省引進(jìn)培育領(lǐng)軍型創(chuàng)新創(chuàng)業(yè)團(tuán)隊(duì)領(lǐng)軍人才,。原任美國MD安德森癌癥中心Ruby E.Rutherford杰出講席終身教授,、腫瘤代謝中心創(chuàng)始主任,。呂教授是腫瘤學(xué)和細(xì)胞信號轉(zhuǎn)導(dǎo)研究領(lǐng)域國際知名的杰出科學(xué)家,，對腫瘤細(xì)胞能量代謝的研究取得了開創(chuàng)性,、系統(tǒng)性的重要成果，在國際上首次揭示了多種代謝酶具有蛋白激酶活性,，首次系統(tǒng)性地闡明了生長因子受體促進(jìn) Warburg 效應(yīng)的調(diào)控機(jī)制,，率先證實(shí)了多種代謝酶和代謝物在腫瘤細(xì)胞活動調(diào)控中具有重要的非代謝功能。
呂志民教授2013年獲得M.D.安德森癌癥中心Potu N. Rao基礎(chǔ)科學(xué)卓越獎,、2016年獲得M.D.安德森癌癥中心Dallas/Fort Worth傳奇人物基礎(chǔ)研究成就獎,、2017年當(dāng)選美國科學(xué)促進(jìn)會（AAAS）會士。2021年當(dāng)選歐洲科學(xué)院Academia Europaea外籍院士,。受邀擔(dān)任精準(zhǔn)醫(yī)學(xué)雜志榮譽(yù)主編,，Visualized Cancer Medicine 主編，Journal of National Cancer Center副主編,， Cell Research,、The Journal of Biological Chemistry等10余個期刊的編委。
呂志民教授先后在Nature（4篇）,、Cell（2篇）,、Nature Cell Biology（5篇）、Molecular Cell（15篇）,、Cancer Cell,、Cancer Discovery、Cell Metabolism,、Nature Reviews Molecular Cell Biology等發(fā)表論文100多篇,，其中在Cell,、Nature、Science系列雜志中發(fā)表論文40余篇,。其原創(chuàng)性里程碑發(fā)現(xiàn)深刻影響了業(yè)界對腫瘤代謝的認(rèn)識,，同時也對開拓新的腫瘤診治方法提供了創(chuàng)新理論支持。
專業(yè)擅長
腫瘤代謝
研究方向
腫瘤代謝
成果獎項(xiàng)：（近五年主要成果及獎勵情況）
1. Ji H, Lee J, Wang Y, Pang Y, Zhang T, Xia Y, Zhong L, Lyu J, Lu Z*. EGFR phosphorylates FAM129B to promote Ras activation. PNAS. 1/2016. 113(3):644-9. PMID:26721396.
2. Li X, Jiang Y, Meisenhelder J, Yang W, Hawke D, Zheng Y, Xia Y, Aldape K, He J, Hunter T, Wang L, and Lu Z*. Mitochondria-translocated phosphoglycerate kinase 1 functions as a protein kinase to coordinate glycolysis and TCA cycle in tumorigenesis. Molecular Cell. 3/2016. 61(5):705-719. PMID:26942675. (highlighted by MD Anderson news release).
3. Li X, Qian X, Peng L, Jiang Y, Hawke D, Zheng Y, Xia Y, Lee J, Cote G, Wang H, Wang L, Qian C, and Lu Z*. A Splicing Switch from Ketohexokinase-C to Ketohexokinase-A drives hepatocellular carcinoma formation. Nature Cell Biology, 5/2016. 18(5):561-71. PMID:2708854. (Highlighted by Cancer Discovery, Science Signaling, and an MD Anderson news release).
4. Liang J, Cao R, Zheng Y, Xia Y, Zheng Y, Li X, Wang L, Yang W* and Lu Z*. PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis. Nature Communications. 8/2016, 7:12431. PMID: 27485204
5. Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, Lee JH, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang BH, Liu DX, Jiang T, Lu Z*. Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy. Molecular Cell. 3/2017, 2;65(5):917-931.PMID: 28238651 (Highlighted by Autophagy and an MD Anderson news release).
6. Xia Y, Yang W, Fa M, Li X, Wang Y, Jiang Y, Zheng Y, Lee JH, Li J, and Lu Z*. RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis. The Journal of Experimental Medicine. 6/2017. 214 (6), 1843-1855. PMID:28507061.
7. Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee J, Li W, Lyu J, Rao G, Zhang X, Qian C, Rozen S, Jiang T, Lu Z*. Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy. Molecular Cell. 6/2017;66(5):684-697. PMID:28552616. (Highlighted by Nature Reviews Molecular Cell Biology and an MD Anderson news release).
8. Lee JH, Liu R, Li J, Zhang C, Wang Y, Cai Q, Qian X, Xia Y, Zheng Y, Piao Y, Chen Q, Groot J, Tao Jiang T, Lu Z*. Stabilization of Phosphofructokinase 1 Platelet Isoform by AKT Promotes Tumorigenesis. Nature Communications. 10/2017; 16;8(1):949. doi: 10.1038/s41467-017-00906-9. PMID: 29038421
9. Wang Y,Guo Y, Liu K, Yin Z, Liu R, Xia Y, Tan L, Yang P, Lee J, Li XJ, Hawke D, Zheng Y, Qian X, Lyu J He J, Xing D*, Tao Y*, Lu Z*. KAT2A Coupled with the a-KGDH Complex Acts as a Histone H3 Succinyltransferase. Nature, 12/2017. 552(7684):273-277. PMID: 29211711 (Highlighted by Cancer Discovery, Faculty of 1000 Prime, and an MD Anderson news release).
10. Qian X, Li X, Tan L, Lee JH, Xia X, Cai Q, Zheng Y, Wang H, Lorenzi P, Lu Z*. Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress. Cancer Discovery, 1/2018: 8(1):94-107. PMID: 29074724.
11. Lu Z* and Hunter T*. Metabolic Kinases Moonlighting as Protein Kinases. Trends in Biochemical Sciences. 4/2018. (4):301-310. PMID: 29463470.
28. Lee JH, Liu R, Li J., Wang YG, Tan L, Li XJ, Qian X, Zhang C, Xia Y, Xu D, Guo W, Ding Z, Du L, Zheng y, Chen Q, Lorenzi PL, Mills GB, Jiang T, and Lu Z*. EGFR-phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation. Molecular Cell, 4/2018 Apr 19;70(2):197-210. PMID: 29677490
12. Li X, Egervari G, Wang Y, Berger SL*, Lu Z*. Regulation of chromatin and gene expression by metabolic enzymes and metabolites. Nature Reviews Molecular Cell Biology. 9/2018.19(9):563-578. PMID: 29930302
13. Li X, Qian X, Jiang H, Xia Y, Zheng Y, Li J, Huang BJ, Fang J, Qian CN, Jiang T, Zeng YX, and Lu Z*. Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication. Molecular Cell, 11/2018. 72 (4): 650-660. PMID: 30392930.
14. Xu D, Li X, Shao F, Lv G, Lv H, Lee J, Qian X, Wang Z, Xia Y, Du L, Zheng Y, Wang H*, Lyu J* and Lu Z*. The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62. Science Advances, 4/2019. 5 (4): eaav4570. PMID: 31032410.
15. Zhu R, Gires O, Zhu L, Liu J, Li J, Yang H, Ju G, Huang J, Ge W, Chen Y, Lu Z*, Hongxia Wang* (* Co-corresponding). TSPAN8 Promotes Cancer Cell Stemness via Activation of Sonic Hedgehog Signaling. Nature Communications, 6/2019. 10(1):2863. PMID: 31253799.
16. Qian X*, Li X, Shi Z, Xia Y, Cai Q, Xu D, Tan L, Du L,Zheng Y, Zhao D, Zhang C, Lorenzi P, You Y, Jiang B, Jiang T, Li H, and Lu Z*. PTEN suppresses glycolysis by dephosphorylating and inhibiting autophosphorylated PGK1. Molecular Cell, 11/2019. 76(3):516-527. PMID: 31492635.
17. Xie Y, Lv X, Ni D, Liu J, Hu Y, Liu Y, Liu Y, Liu R, Zhao H, Lu Z*, Zhou Q*(*Co-corresponding). HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage. Nature Communications, 9/2019. 10(1):4266. PMID: 31537781.
18. Qian X*, Li X, Shi Z, Bai X, Xia Y, Zheng Y, Xu D, Chen F, You Y, Fang J, Hu Z, Zhou Q, Lu Z*. KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis. Molecular Cell, 12/2019. 76(6):885-895. PMID:31629659
19. Li X*, Qian X, Wang B, Xia Y, Zheng Y, Du L, Xu D, Xing D, Depinho R, and Lu Z*. Programmable base editing of mutated TERT promoter inhibits tumor growth. Nature Cell Biology, 2/2020. PMID: 32066906 (Highlighted by Nature Cell Biology, Cancer Research, and Faculty of 1000 Prime).
20. Xu D*, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee J, Du L, Zheng Y, Lv G, Leu J, Wang H, Xing D, Liang T, Hung M*, and Lu Z*. Gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature, 4/2020. 580(7804):530-535. PMID: 32322062.
21. Du L, Lee J, Jiang H, Wang C, Wang S, Zheng Z, Shao F, Xu X, Xia Y, Li J, Zheng Z, Xu Qian X, Li X, Kim H, Xing D, Liu P, Lu Z*, and Lyu J* (* Co-corresponding). b-catenin induces transcriptional expression of PD-L1 to promote tumor immune evasion. Journal of Experimental Medicine, 2020. 217(11):e20191115. PMID: 32860047. (Highlighted in Journal of Experimental Medicine and Rockefeller University News Release).
22. Bian X, Liu R, Meng Y, Xing D, Xu D, and Lu Z. Lipid metabolism and cancer. Journal of Experimental Medicine, 2021. 218 (1): e20201606.
23. Xu D, Shao F, Bian X, Meng Y, Liang T, and Lu Z. The evolving landscape of noncanonical functions of metabolic enzymes in cancer and other pathologies. Cell Metabolism, 1/2021. 33(1):33-50. PMID: 33406403.
24.Wang W, Shao F, Yang X, Wang J, Zhu R, Yang Y, Guo D, Sun Y, Wang J2, Xue Q, Gao S, Gao Y, He J, and Lu Z. METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding. Nature Communications, 6/2021. 12(1):3803. PMID: 34155197.
25.Tong Y, Guo D, Lin SH, Liang J, Yang D, Ma C, Shao F, Li M, Yu Q, Jiang Y, Li L, Fang J, Yu R*, and Lu Z*. SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress of tumor cells. Molecular Cell, 6/2021, 81(11):2303-2316. PMID: 33991485.
26.Liu R*, Lee JH, Yu R, Li J, Tan L, Xia Y, Zheng Y, Bian X, Lorenzi P, Chen Q,* and Lu Z *. Choline kinase alpha 2 acts as a protein kinase to promote the lipolysis of lipid droplets. Molecular Cell, 2021. 7/2021. 81(13):2722-2735. PMID: 34077757 (Highlighted in Molecular Cell).
