崔丹蕊
查看科室更多醫(yī)生性 別：女
最高學(xué)歷、學(xué)位：理學(xué)博士理學(xué)博士
職 稱：特聘研究員
個(gè)人簡(jiǎn)介
崔丹蕊,，博士,，浙江大學(xué)附屬第一醫(yī)院浙江省胰腺病研究重點(diǎn)實(shí)驗(yàn)室特聘研究員。長(zhǎng)期從事CRL泛素連接酶在腫瘤發(fā)生發(fā)展中的作用,、抗腫瘤藥物作用機(jī)制和腫瘤放化療增敏機(jī)制等方面的研究工作,。迄今為止，在國(guó)際權(quán)威刊物上發(fā)表SCI論文14篇,，包括Cell Death and Differentiation,、Cell Reports、Cell Death & Disease,、Oncogene,、Molecular Oncology、BBA-Molecular Cell Research和Cell Division等一作或共同一作7篇,。作為課題負(fù)責(zé)人主持國(guó)家自然科學(xué)基金青年科學(xué)基金項(xiàng)目1項(xiàng),。
專業(yè)擅長(zhǎng)
1.利用基因工程小鼠研究腫瘤的發(fā)生發(fā)展
2.利用生化分子細(xì)胞手段研究腫瘤細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)
研究方向
1. Cullin-RING Ligase (CRL) E3泛素連接酶在腫瘤發(fā)生中的功能
2. Neddylation信號(hào)通路在腫瘤發(fā)生中的功能
成果獎(jiǎng)項(xiàng)：（近五年主要成果及獎(jiǎng)勵(lì)情況）
代表論文（#：共同第一作者；*：通訊作者）
1. Cui D; Dai X; Shu J; Ma Y; Wei D; Xiong X; Zhao Y*; The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth, Cell Death and Differentiation, 2020, 27(3): 1119-1133. (IF=15.828)
2. Cui D#; Xiong X#; Shu J; Dai X; Sun Y; Zhao Y*; FBXW7 confers radiation survival by targeting p53 for degradation, Cell Reports, 2020, 30(2): 497-509. (IF=10.394)
3. Cui D#; Dai X#; Gong L; Chen X; Wang L; Xiong X; Zhao Y*; DEPTOR is a direct p53 target that suppresses cell growth and chemosensitivity, Cell Death & Disease, 2020, 11(11): 976. (IF=8.469)
4. Chen X#; Xiong X#; Cui D#; Yang F; Wei D; Li H; Shu J; Bi Y; Dai X; Gong L; Sun Y; Zhao Y*; DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals, Oncogene, 2020, 39(7): 1557-1571. (IF=9.867)
5. Ma Y#; Cui D#; Xiong X; Inuzuka H; Wei W; Sun Y; North B J*; Zhao Y*; SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation, Molecular Oncology, 2019,13(2): 307-321. (IF= 7.405)
6. Wang J#; Cui D#; Gu S; Chen X; Bi Y; Xiong X; Zhao Y*; Autophagy regulates apoptosis by targeting NOXA for degradation, Biochimica et Biophysica Acta-Molecular Cell Research, 2018, 1865(8): 1105-1113. (IF=6.121)
