沈一飛
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出診信息
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個人簡介
浙江大學(xué)醫(yī)學(xué)院特聘副研究員,，浙江省臨床體外診斷技術(shù)研究重點實驗室 PI
專業(yè)擅長
多組學(xué)人工智能診斷及生物信息學(xué)大數(shù)據(jù)分析
研究方向
基于機器學(xué)習(xí)和數(shù)據(jù)挖掘技術(shù)的多維組學(xué)數(shù)據(jù)分子標(biāo)志物識別，重大疾病早期篩查及預(yù)后評估,。
成果獎項：（近五年主要成果及獎勵情況）
1. Serum level of testosterone predicts disease severity of male COVID-19 patients and is related to T-cell immune modulation by transcriptome analysis[J]. Clinica Chimica Acta, 2022
2. scDetect: a rank-based ensemble learning algorithm for cell type identification of single-cell RNA sequencing in cancer. Bioinformatics (2021).
3. TOD-CUP: a gene expression rank-based majority vote algorithm for tissue origin diagnosis of cancers of unknown primary. Briefings in Bioinformatics (2021).
4. Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood–Derived NK Cells Facilitates CAR-like Responses Against CD30+ Malignancies.” Clinical Cancer Research 27 (13), (2021): 3744-3756
5. Targeting the αv integrin-TGF-β axis improves natural killer cell function against glioblastoma stem cells. The Journal of Clinical Investigation, (2021)
6. Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells. Blood, The Journal of the American Society of Hematology 137 (5), (2021): 624-636
7. Genome‐wide selection footprints and deleterious variations in young Asian allotetraploid rapeseed. Plant biotechnology journal 17, no. 10 (2019): 1998-2010.
8. A naive Bayes algorithm for tissue origin diagnosis (TOD-Bayes) of synchronous multifocal tumors in the hepatobiliary and pancreatic system. International journal of cancer 142, no. 2 (2018).
9. Analysis of transcriptional and epigenetic changes in hybrid vigor of allopolyploid Brassica napus uncovers key roles for small RNAs. The Plant Journal 91, no. 5 (2017).
10. Transcriptome sequencing reveals e-cigarette vapor and mainstream-smoke from tobacco cigarettes activate different gene expression profiles in human bronchial epithelial cells. Scientific reports 6, no. 1 (2016).
