李明定
查看科室更多醫(yī)生性 別：男
最高學(xué)歷,、學(xué)位：博士
職 稱：教授
院內(nèi)職務(wù)：無
個(gè)人簡(jiǎn)介
浙江大學(xué)求是講席教授,、博導(dǎo),、國(guó)家精準(zhǔn)醫(yī)療重大專項(xiàng)首席科學(xué)家,。
李明定教授長(zhǎng)期從事以生物信息學(xué)和分子數(shù)量遺傳學(xué)為基礎(chǔ)的人類遺傳學(xué),、藥理基因組學(xué),、神經(jīng)生物學(xué)和遺傳流行病學(xué)等領(lǐng)域的研究,，所領(lǐng)導(dǎo)的復(fù)雜疾病遺傳和生物信息研究室是世界上第一個(gè)用基因芯片和蛋白組學(xué)來研究尼古丁對(duì)人類以及模式動(dòng)物基因組影響的研究室,，也是第一個(gè)用全基因組連鎖方法成功地定位美國(guó)黑人群體尼古丁成癮基因的研究室。李明定教授在 Nature Genetics Reviews, Nature Genetics, American Journal of Human Genetics 和 Molecular Psychiatry 等國(guó)際重要刊物上以第一作者或通論作者發(fā)表SCI學(xué)術(shù)論文共230多篇,，總影響因子約1000,，平均每篇5.5，它引高達(dá)8000多次,，單篇最高600余次,，并主編出版了四本英文專著和一本中文專著。
專業(yè)擅長(zhǎng)
人類復(fù)雜疾病的遺傳學(xué)分析
生物信息學(xué)
研究方向
精準(zhǔn)醫(yī)學(xué)和個(gè)體化醫(yī)學(xué)研究
基因組學(xué)和藥物基因組學(xué)研究
生物信息學(xué)
遺傳流行病學(xué)
人工智能在醫(yī)學(xué)中的應(yīng)用
成果獎(jiǎng)項(xiàng)：（近五年主要成果及獎(jiǎng)勵(lì)情況）
（1） Chen, J., Y. Ma, R. Fan, Z. Yang and M. D. Li (2018). "Implication of Genes for the N-Methyl-D-Aspartate (NMDA) Receptor in Substance Addictions." Mol Neurobiol 55(9): 7567-7578.
（2） Cui, W., Y. Ning, W. Hong, J. Wang, Z. Liu and M. D. Li (2019). "Crosstalk Between Inflammation and Glutamate System in Depression: Signaling Pathway and Molecular Biomarkers for Ketamine's Antidepressant Effect." Mol Neurobiol 56(5): 3484-3500.
（3） Fan, R., W. Cui, J. Chen, Y. Ma, Z. Yang, T. J. Payne, J. Z. Ma and M. D. Li (2020). "Gene-based association analysis reveals involvement of LAMA5 and cell adhesion pathways in nicotine dependence in African- and European-American samples." Addict Biol: e12898.
（4） Fang, Z., Y. Yang, Y. Hu, M. D. Li and J. Wang (2017). "GRONS: a comprehensive genetic resource of nicotine and smoking." Database (Oxford) 2017.
（5） Han, H., Q. Liu, Z. Yang, M. Wang, Y. Ma, L. Cao, W. Cui, W. Yuan, T. J. Payne, L. Li and M. D. Li (2018). "Association and cis-mQTL analysis of variants in serotonergic genes associated with nicotine dependence in Chinese Han smokers." Transl Psychiatry 8(1): 243.
（6） Han, H., Z. Yang, S. L. Chang and M. D. Li (2018). "Modulatory Effects of Nicotine on neuroHIV/neuroAIDS." J Neuroimmune Pharmacol 13(4): 467-478.
（7） Hu, T., Z. Yang and M. D. Li (2018). "Pharmacological Effects and Regulatory Mechanisms of Tobacco Smoking Effects on Food Intake and Weight Control." J Neuroimmune Pharmacol 13(4): 453-466.
（8） Jiang, X., B. Zhang, J. Zhao, Y. Xu, H. Han, K. Su, J. Tao, R. Fan, X. Zhao, L. Li and M. D. Li (2019). "Identification and characterization of SEC24D as a susceptibility gene for hepatitis B virus infection." Sci Rep 9(1): 13425.
（9） Li, J., Y. Ma, Z. Bao, X. Gui, A. N. Li, Z. Yang and M. D. Li (2020). "Clostridiales are predominant microbes that mediate psychiatric disorders." J Psychiatr Res 130: 48-56.
（10） Liu, Q., H. Han, M. Wang, Y. Yao, L. Wen, K. Jiang, Y. Ma, R. Fan, J. Chen, K. Su, Z. Yang, W. Cui, W. Yuan, X. Jiang, J. Li, T. J. Payne, J. Wang and M. D. Li (2018). "Association and cis-mQTL analysis of variants in CHRNA3-A5, CHRNA7, CHRNB2, and CHRNB4 in relation to nicotine dependence in a Chinese Han population." Transl Psychiatry 8(1): 83.
（11） Liu, Q., Y. Xu, Y. Mao, Y. Ma, M. Wang, H. Han, W. Cui, W. Yuan, T. J. Payne, Y. Xu, M. D. Li and Z. Yang (2020). "Genetic and Epigenetic Analysis Revealing Variants in the NCAM1-TTC12-ANKK1-DRD2 Cluster Associated Significantly With Nicotine Dependence in Chinese Han Smokers." Nicotine Tob Res 22(8): 1301-1309.
（12） Liu, W. and M. D. Li (2018). "Insights Into Nicotinic Receptor Signaling in Nicotine Addiction: Implications for Prevention and Treatment." Curr Neuropharmacol 16(4): 350-370.
（13） Ma, Y., J. Li, Y. Xu, Y. Wang, Y. Yao, Q. Liu, M. Wang, X. Zhao, R. Fan, J. Chen, B. Zhang, Z. Cai, H. Han, Z. Yang, W. Yuan, Y. Zhong, X. Chen, J. Z. Ma, T. J. Payne, Y. Xu, Y. Ning, W. Cui and M. D. Li (2020). "Identification of 34 genes conferring genetic and pharmacological risk for the comorbidity of schizophrenia and smoking behaviors." Aging (Albany NY) 12(3): 2169-2225.
（14） Ma, Y. and M. D. Li (2017). "Establishment of a Strong Link Between Smoking and Cancer Pathogenesis through DNA Methylation Analysis." Sci Rep 7(1): 1811.
（15） Pan, Z., M. Zhao, Y. Peng and J. Wang (2019). "Functional divergence analysis of vertebrate neuronal nicotinic acetylcholine receptor subunits." J Biomol Struct Dyn 37(11): 2938-2948.
（16） Wang, M., J. Zhao, Y. Wang, Y. Mao, X. Zhao, P. Huang, Q. Liu, Y. Ma, Y. Yao, Z. Yang, W. Yuan, W. Cui, T. J. Payne and M. D. Li (2020). "Genome-wide DNA methylation analysis reveals significant impact of long-term ambient air pollution exposure on biological functions related to mitochondria and immune response." Environ Pollut 264: 114707.
（17） Wen, L., H. Han, Q. Liu, K. Su, Z. Yang, W. Cui, W. Yuan, Y. Ma, R. Fan, J. Chen, K. Jiang, X. Jiang, T. J. Payne, J. Wang and M. D. Li (2017). "Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population." Sci Rep 7(1): 9745.
（18） Xu, Y., L. Cao, X. Zhao, Y. Yao, Q. Liu, B. Zhang, Y. Wang, Y. Mao, Y. Ma, J. Z. Ma, T. J. Payne, M. D. Li and L. Li (2020). "Prediction of Smoking Behavior From Single Nucleotide Polymorphisms With Machine Learning Approaches." Front Psychiatry 11: 416.
（19） Yang, Z., J. Li, X. Gui, X. Shi, Z. Bao, H. Han and M. D. Li (2020). "Updated review of research on the gut microbiota and their relation to depression in animals and human beings." Mol Psychiatry 25(11): 2759-2772.
（20） Yang, Z., T. Nesil, T. Wingo, S. L. Chang and M. D. Li (2017). "HIV-1 Proteins Influence Novelty-Seeking Behavior and Alter Region-Specific Transcriptional Responses to Chronic Nicotine Treatment in HIV-1Tg Rats." Nicotine Tob Res 19(9): 1024-1032.
（21） Yao, Y., Y. Xu, Z. Cai, Q. Liu, Y. Ma, A. N. Li, T. J. Payne and M. D. Li (2020). "Determination of shared genetic etiology and possible causal relations between tobacco smoking and depression." Psychol Med: 1-10.
（22） Yao, Y., Y. Xu, J. Zhao, Y. Ma, K. Su, W. Yuan, J. Z. Ma, T. J. Payne and M. D. Li (2018). "Detection of Significant Association Between Variants in Cannabinoid Receptor 1 Gene (CNR1) and Personality in African-American Population." Front Genet 9: 199.
Zhao, X., M. Xu, Z. Cai, W. Yuan, W. Cui and M. D. Li (2019). "Identification of LIFR, PIK3R1, and MMP12 as Novel Prognostic Signatures in Gallbladder Cancer Using Network-Based Module Analysis." Front Oncol 9: 325.
